Loss of Heterozygosity in Normal Tissue Adjacent to Breast Carcinomas
نویسندگان
چکیده
منابع مشابه
Loss of heterozygosity in normal tissue adjacent to breast carcinomas.
Loss of heterozygosity (LOH) was detected in morphologically normal lobules adjacent to breast cancers. The most frequent aberration was at chromosome 3p22-25; of ten cases with this LOH in the carcinoma, six displayed the same LOH in adjacent normal lobules. This suggests that in a subset of sporadic breast cancers, a tumor suppresser gene at 3p22-25 may be important in initiation or early pro...
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ژورنال
عنوان ژورنال: Science
سال: 1996
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.274.5295.2057